Le Gouvernement du Grand-Duché du Luxembourg
Horizon Europe call deadlines Autumn 2025

Research Infrastructure 2025

Research Infrastructures 2025

HORIZON-INFRA-2025-01

18 September 2025

  • Training and up-skilling of research infrastructures technical staff
  • Early phase implementation of ESFRI Projects that entered the ESFRI Roadmap in 2021
  • Consolidation of the Research Infrastructure landscape – Individual support for evolution, long term sustainability and emerging needs of pan-European research infrastructures
  • Support to the European Strategy Forum on Research Infrastructures
  • Preparatory actions exploring future frameworks for research infrastructures investment plans and funding streams, for integrated and sustained scheme for access and for joint technology development.
  • EOSC Nodes with federating capabilities for the EOSC Federation
  • FAIR Integration for Enhanced Research Data in the EOSC ecosystem and beyond
  • Advancing AI-readiness and Machine-Actionability in the EOSC Ecosystem
  • Data stewards, skills and training for Open Science and FAIR practices
  • Using Generative AI (GenAI4EU ) for Scientific Research via EOSC
  • Research infrastructure services to enable R&I addressing main challenges and EU priorities related to the health domain
  • Research infrastructure services to enable R&I addressing main challenges and EU priorities
  • Research infrastructure services advancing frontier knowledge
  • Research infrastructure services advancing frontier knowledge (bottom-up)
  • New technologies and solutions for reducing the environmental and climate footprint of research infrastructures
  • Implementing research infrastructure technology roadmaps
  • AI-powered impact simulations in support of the Destination Earth initiative
  • AI-generated digital twins for science

European Innovation Council (EIC)

EIC Accelerator 2025 - Short application

HORIZON-EIC-2025-ACCELERATOR-01

17 December 2025

  • EIC Accelerator 2025 - Short application

EIC Pathfinder Challenges 2025

29 October 2025

  • Biotech for Climate Resilient Crops and Plant-Based Biomanufacturing
  • Generative-AI based Agents to Revolutionize Medical Diagnosis and Treatment of Cancer
  • Towards autonomous robot collectives delivering collaborative tasks in dynamic unstructured construction environments
  • Waste-to-value devices - circular production of renewable fuels, chemicals and materials
EIC Transition 2025

HORIZON-EIC-2025-TRANSITIONOPEN

17 September 2025

  • -
Women Tech.EU initiative

HORIZON-EIC-2025-WOMENTECH

02 September 2025

  • Women Tech.EU initiative

Interconnected Innovation Ecosystems (2025.2)

HORIZON-EIE-2025-02

15 October 2025

  • Preparatory action for setting up joint programmes among innovation ecosystems actors
  • Implementing co-funded action plans for connected regional innovation valleys

Cluster 1: Health

Cluster 1: Health

HORIZON-HLTH-2025-01 (Single Stage)

16 September 2025

  • End user-driven application of Generative Artificial Intelligence models in healthcare (GenAI4EU)
  • Testing safety and efficacy of phage therapy for the treatment of antibiotic-resistant bacterial infections
  • Development of antibodies and antibody-derived proteins for the prevention and treatment of infectious diseases with epidemic potential
  • Leveraging artificial intelligence for pandemic preparedness and response
  • Support for the functioning of the Global Research Collaboration for Infectious Disease Preparedness (GloPID-R)
  • Implementation research addressing strategies to strengthen health systems for equitable high-quality care and health outcomes in the context of non-communicable diseases (GACD)
  • Tackling high-burden for patients and under-researched medical conditions
  • Optimising the manufacturing of Advanced Therapy Medicinal Products (ATMPs)
  • Digitalisation of conformity assessment procedures of medical devices and in vitro diagnostic medical devices
  • Enhancing cell therapies with genomic techniques
  • Advancing cell secretome-based therapies
  • Leveraging multimodal data to advance Generative Artificial Intelligence applicability in biomedical research (GenAI4EU)
  • Boosting the translation of biotech research into innovative health therapies

Cluster 2: Culture, Creativity and Inclusive Society

HORIZON-HLTH-2025-03-two-stage

16 September 2025

  • Advancing innovative interventions for mental, behavioural and neurodevelopmental disorders
  • The impact of pollution on the development and progression of brain diseases and disorders
  • Advancing knowledge on the impacts of micro- and nanoplastics on human health
  • Facilitating the conduct of multinational clinical studies of orphan devices and/or of highly innovative (“breakthrough”) devices
  • Improving the quality of life of persons with intellectual disabilities and their families

Cluster 2: Culture, Creativity and Inclusive Society

Cluster 2: Culture, Creativity and Inclusive Society

HORIZON-CL2-2025-01

16 september 2025

  • Advisory support and network to counter disinformation and foreign information manipulation and interference (FIMI)
  • Fostering the consolidation of European science diplomacy
  • Preparing the EU for future enlargement: challenges and opportunities
  • Open strategic autonomy, economic and research security in EU foreign policy
  • Countering and preventing radicalisation, extremism, hate speech and polarisation
  • Towards a European research hub on contemporary antisemitism and Jewish life and culture
  • The autocratic appeal: nature, drivers and strategies
  • Economic inequalities and their impact on democracy
  • Fighting against disinformation while ensuring the right to freedom of expression
  • The role of civic and citizenship education for strengthening civic and democratic participation and support for common European values
  • Independence of the judiciary as an aspect of rule of law compliance
  • Community of democracy practitioners and researchers
  • A European Collaborative Cloud for Cultural Heritage – Innovative use cases
  • Leveraging artificial intelligence for creativity-driven innovation
  • Evolution of culture in a virtualising world
  • Europe as a global powerhouse of design for sustainable competitiveness
  • Cultural Strategies for Peace: culture and creativity as catalysts for conflict prevention and post-conflict reconciliation
  • Bridging historical past and future potential through conservation, preservation, and adaptive use of Europe’s contentious and dissonant heritage
  • Impacts of culture and the arts on health and well-being
  • Tackling gender-based violence in different social and economic spheres
  • Historical and regional analyses of industrial transitions and their lessons for ensuring a fair green transition
  • Working time reduction: barriers, challenges, benefits and policy implications
  • Improving fairness in the economy through a better understanding of undeclared and underdeclared work
  • Evaluation and use of evidence in education policy and practice
  • Impact of the learning environment and the use of digital tools in everyday life on key skills and competence development
  • Improving mental health outcomes for people in education, training and work
  • Good practices for increased autonomy of persons with disabilities, including physical, mental, intellectual and sensory disabilities
  • Intergenerational fairness in the context of demographic change in the EU

Cluster 2: Culture, Creativity and Inclusive Society

HORIZON-CL2-2025-02-TWO-STAGE

16 September 2025

  • Innovative approaches to intangible cultural heritage for societal resilience
  • Gender differences in career trajectories of parents and their implications for gender equality and family well-being

Cluster 3

Cluster 3

HORIZON-CL3-2025-01

12 November 2025

  • Open topic on better customs and supply chain security
  • Open topic on citizen and regional and/or local authorities' engagement in enhanced disaster risk awareness, including education, and preparedness
  • Open topic on Improving disaster risk management and governance to ensure self-sufficiency and sustainability of operations in support of enhanced resilience
  • Open topic on testing / validating tools, technologies and data used in cross-border prevention, preparedness and responses to climate extreme and geological events and chemical, biological or radiological emergency threats
  • Advancing autonomous systems and robotics for high-risk disaster response, strengthening disaster resilience in conflict-afflicted crisis zones
  • Open topic on modern information and forensic evidence analysis and on frontline policing
  • Open topic on prevention, detection and deterrence of various forms of crime and terrorism through an enhanced understanding of the related societal issues
  • Open topic on improved intelligence picture and enhanced prevention, detection and deterrence of various forms of organised crime
  • Humanitarian demining / Unexploded Ordnance Disposal (UXO) of civil areas and unexploded ordnance risk education
  • Open topic for improved preparedness for, response to and recovery from large-scale disruptions of critical infrastructures
  • Open topic for role of the human factor for the resilience of critical infrastructures
  • National Contact Points (NCPs) in the field of security and cybersecurity fostering the links with National Community building for Safe, Secure and Resilient Societies
  • Uptake Acceleration Services
  • Open grounds for pre-commercial procurement of innovative security technologies
  • Accelerating uptake through open proposals for advanced SME innovation
  • Data repository for security research and innovation
  • Demand-led innovation for civil security through Pre-Commercial Procurement (PCP)

Cluster 4: Digital, Industry and Space

DIGITAL

HORIZON-CL4-2025-03

02 october 2025

  • Large-scale pilots for supply end-to-end infrastructures integrating device, network computing and communication capabilities for Telco Edge Cloud deployments, as a basis for Connected Collaborative Computing Networks (3C networks) (RIA)
  • Alignment of stakeholders towards the supply-side large-scale pilot of end-to-end infrastructures integrating device, network computing and communication capabilities (CSA)
  • Roadmap for next generation computing technologies from IoT device level to edge to cloud to HPC (CSA)
  • Open Internet Stack: development of technological commons/open-source 3C building blocks (RIA)
  • Preparing the Advancement of the state of the art of submarine cable infrastructures (CSA)
  • Fostering Innovative and Compliant Data Ecosystems (IA) (AI, Data and Robotics Partnership)
  • Continuation of the Quantum Technologies Flagship (CSA)
  • Quantum Computing – complementing the quantum computing FPAs with the development of a technology agnostic software stack (RIA)
  • Supporting Digital Partnerships in Quantum technologies (RIA)
  • Post-exascale HPC (CSA)
  • Robust and trustworthy GenerativeAI for Robotics and industrial automation (RIA) (AI/Data/Robotics & Made in Europe Partnerships)
  • Strengthening the fabless Start-up and SME ecosystem in Europe (CSA)
  • Challenge-Driven GenAI4EU Booster (RIA) (AI/Data/Robotics Partnership)
  • Core technologies for virtual worlds (RIA) (Virtual Worlds and Photonics Partnerships)
  • Core technologies for virtual worlds (RIA) (Virtual Worlds and Photonics Partnerships)
  • Drive the evolution of the internet towards open and interoperable Web 4.0 and Virtual Worlds: building blocks in priority areas (RIA) (Virtual Worlds Partnership)
  • Specific support for the Virtual Worlds Partnership and the Web 4.0 initiative (CSA) (Virtual Worlds Partnership)
  • GenAI4EU central Hub (CSA) (AI/Data/Robotics Partnership)
  • International cooperation in semiconductors (CSA)
  • Innovative Advanced Materials (IAMs) for photonics, enabling low-power and ultra-broadband performance for telecommunication (RIA) (Innovative Advanced Materials for Europe partnership)
  • Innovative Advanced Materials (IAMs) for conformable, flexible or stretchable electronics (RIA) (Innovative Advanced Materials for Europe partnership)
DIGITAL

HORIZON-CL4-2025-04

02 octobre 2025

  • Empowering AI/generative AI along the Cognitive Computing continuum (RIA) (AI/Data/Robotics Partnership)
  • Software Engineering for AI and generative AI (RIA) (AI/Data/Robotics Partnership)
  • Advanced sensor technologies and multimodal sensor integration for multiple application domains (IA) (Photonics Partnership)
  • Assessment methodologies for General Purpose AI capabilities and risks (RIA) (AI/Data/Robotics Partnership)
  • Soft Robotics for Advanced physical capabilities (IA) (AI/Data/Robotics Partnership)
  • Enhanced Learning Strategies for General Purpose AI: Advancing GenAI4EU (RIA) (AI/Data/Robotics Partnership)
  • GenAI for Africa
INDUSTRY

HORIZON-CL4-2025-01

23 september 2025

  • AI Foundation models in science (GenAI4EU) (RIA)
  • Facilitated cooperation for AI in Science (CSA)
  • Horizon Standardisation Booster (CSA)
  • Standardisation landscape analyses tool (CSA)
  • Artificial Intelligence for knowledge valorisation (CSA)
  • Value creation pilots for scaling up innovative solutions (CSA)
  • Pilot initiatives on Technology Infrastructures (CSA)
  • System innovation experimentation for Industry 5.0 (IA)
  • Assessment of Technology Infrastructure needs in Ukraine (CSA)
  • Digitally enabled local-for-local textile and apparel production (Textiles for the Future Partnership) (IA)
  • Innovative Advanced Materials Innovation Procurement (CSA)
  • Materials Commons for Europe (IA)
  • Accelerate the uptake of life-cycle assessment (LCA) for Safe and Sustainable by Design (SSbD) chemicals and materials and resulting products (RIA)
  • Technologies for critical raw materials and strategic raw materials from end-of-life products (IA)
  • Strategic Partnerships for Raw Materials: Innovative Approaches for sustainable production of Critical Raw Materials (IA)
  • Innovative solutions for the sustainable production for Semiconductor raw materials (IA)
  • EU Co-funded Partnership on raw materials for the green and digital transition (Co-funded partnership Raw Materials for the Green and Digital Transition)
  • Integrated approaches for remanufacturing (Made in Europe Partnership) (IA)
  • Physical and cognitive augmentation in advanced manufacturing (Made in Europe Partnership) (RIA)
  • Advanced manufacturing technologies for leadership of EU manufacturers in products for the net-zero industry (Made in Europe Partnership) (IA)
  • From heat-driven processes to the use of mechanical and electric forces (Processes4Planet partnership) (IA)
  • Green and resilient flexible production processes (Processes4Planet partnership) (IA)
  • Integrated use of renewable energy carriers in industrial sites (Processes4Planet partnership) (RIA)
  • Safe and clean processing technologies and products (Processes4Planet partnership) (RIA)
  • Smart integration of net zero technologies into Energy Intensive industries (Processes4Planet and Made in Europe partnerships) (IA)
  • Solving issues in carbon-neutral iron and steel making processes with diverse input materials of varying quality (Clean Steel Partnership) (RIA)
  • Synergies and mutual learning with national and regional initiatives in Europe on Industrial decarbonisation (CSA)
  • Towards human-centric, sustainable and resilient energy-intensive industries (Processes4Planet and Clean Steel partnerships) (CSA)

INDUSTRY two-stage

HORIZON-CL4-2025-05-two-stage

23 septembre 2025

  • Innovative Advanced Materials (IAMs) for product monitoring, smart maintenance and repair strategies in the construction sector (RIA) (Innovative Advanced Materials for Europe partnership)
  • Innovative Advanced Materials (IAMs) for robust, fast curing sealants and coatings for manufacturing and final assembly (IA) (Innovative Advanced Materials for Europe partnership)
  • Development of safe and sustainable by design alternatives to Perfluoroalkyl and Polyfluoroalkyl Substances (PFAS) (IA)
  • Enhanced logistics and operations of construction sites (IA)
  • Demonstrators for clusters of social circular enterprises (IA)
  • Developing and embedding upcycling technologies into viable business (Processes4Planet partnership) (IA)

Cluster 5: Climate, Energy and Mobility 

Cluster 5: Climate, Energy and Mobility 

HORIZON-CL5-2025-01-Two-Stage

02 septembre 2025 

  • Cost-effective next-generation batteries for long-duration stationary storage (Batt4EU Partnership)
  • Critical elements for energy security of grid and storage technologies
Cluster 5: Climate, Energy and Mobility 

HORIZON-CL5-2025-02

02 September 2025

  • Sustainable processing and refining of raw materials to produce battery grade Li-ion battery materials (Batt4EU Partnership)
  • Fostering the European battery ecosystem by providing accurate and up-to-date information and stimulating excellence in the European battery R&I community (Batt4EU Partnership)
  • Coordinated call with India on waste to renewable hydrogen
  • Clean Energy Transition Co-Funded Partnership
  • Support to the SET Plan community
  • NZIA regulatory sandbox exchange forum support
  • Novel approaches to geothermal resources development
  • Development of hydropower technologies and water management schemes allowing for win-win situation of flexible hydropower and biodiversity improvement – Societal Readiness Pilot
  • Innovative manufacturing of wind energy technologies
  • Optimised/Alternative Silicon Growth Technologies (from either liquid or gaseous phase) for PV Applications (EUPI-PV Partnership)
  • Novel inverter technologies and flexibility in PV systems (EUPI-PV Partnership)
  • Building a Long-Term Africa Union (AU) and European Union (EU) Research and Innovation joint collaboration on Sustainable Renewable Energies
  • Support to the BRIDGE initiative
  • Control and operation tools for a RES-based energy system
  • Cross-regional network and market model for optimisation of long duration storage
  • Effects of CO2-stream impurities on CO2 transport and storage
  • European investment atlas of potential CO2 storage sites
  • Using captured CO2 as a resource to replace fossil hydrocarbons in industrial production
Cluster 5: Climate, Energy and Mobility 

HORIZON-CL5-2025-04

04 septembre 2025

  • Efficient wireless stationary bidirectional charging solutions for road Light Duty Vehicles (2ZERO Partnership) – Societal Readiness Pilot
  • Cybersecure and resilient road e-mobility ecosystem (2ZERO Partnership)
  • Safe post-crash management of road Light Duty Battery Electric Vehicles (BEVs) (2ZERO Partnership)
  • Extended lifetime of road Battery Electric Vehicles (BEV) (2ZERO Partnership)
  • Extended lifetime of road Battery Electric Vehicles (BEV) (2ZERO Partnership)
  • Strategies, tools and concepts for optimised road Battery Electric Vehicles (BEV) long-haul logistics use cases (2ZERO Partnership)
  • Accelerating the circular transformation of the EU automotive industry
  • Next generation testing capabilities in strategic EU wind tunnels
  • Innovative solutions for energy conversion and safety of low and zero-carbon fuels in waterborne transport (ZEWT Partnership)
  • Demonstration of battery energy storage systems in existing and new vessels via novel energy storage and ship design concepts (ZEWT Partnership)
  • Real-time, adaptative and innovative energy management solutions to optimise fuel consumption and lower emissions pollutants in waterborne transport (ZEWT Partnership)
  • Novel holistic intelligent tools for variable retrofit and decarbonised scenarios (ZEWT Partnership)
  • Flexible and mobile solutions for Onshore Power Supply (ZEWT Partnership)
  • Optimal integrated onboard renewable energy solutions, by considering Wind-Assisted Propulsion Systems (ZEWT Partnership)
  • Support of the new EU renewable and low carbon fuel ecosystem for waterborne transport
  • Support to the organisation and dissemination of the Transport Research Arena (TRA) conference
  • Knowledge sharing and dissemination to support road transport R&I in EU and around the world increasing global EU competitiveness
  • Advancing remote operations to enable the sustainable and smart mobility of people and goods based on operational and societal needs (CCAM Partnership) – Societal Readiness Pilot
  • Preparing for large-scale CCAM demonstrations (CCAM Partnership) – Societal Readiness Pilot
  • Innovative air mobility and services for sustainable and smart urban, peri-urban transport – Societal Readiness pilot
  • Safe Human-Technology Interaction (HTI) in the vehicle systems of the coming decade – Societal Readiness Pilot
Cluster 5: Climate, Energy and Mobility 

HORIZON-CL5-2025-05-Two-Stage

04 Septembre 2025

  • Adaptation to Climate Change: Effectiveness and Limits
Cluster 5: Climate, Energy and Mobility 

HORIZON-CL5-2025-06

23 September 2025

  • Climate simulations data and knowledge for optimal support of IPCC Assessments and International Policy
  • Advancing Earth System Models to increase understanding of Earth system change
  • Modelling of mitigation pathways for F-gases
  • The attribution to climate change, and improved forecasting of extreme and slow-onset climate- and weather-related events and their impacts
  • Fostering equity and justice in climate policies – Societal Readiness Pilot
  • Implementing the climate action pillar of the EU-African Union Partnership on Climate Change and Sustainable Energy
  • Driving Urban Transitions to a sustainable future (DUT) Co-Funded Partnership
  • Large-scale production of liquid advanced biofuels and renewable fuels of non-biological origin
  • Competitiveness, energy security and integration aspects of advanced biofuels and renewable fuels of non-biological origin value chains
  • Demonstration of thermal energy storage solutions for solar thermal plants and systems
  • Improved reliability and optimised operations and maintenance for wind energy systems
  • Understand and minimise the environmental impacts of offshore wind energy
  • Towards commercialisation of Perovskite PV and development of dedicated manufacturing equipment (EUPI-PV Partnership)
  • Extending the lifetime of crystalline silicon PV modules (EUPI-PV Partnership)
  • De-risking wave energy technology development through transnational pre-commercial procurement of wave energy research and development
  • Development of innovative solutions strengthening the security of renewable energy value chains
  • Next generation distribution substation for increasing the system resilience
  • Innovative solutions for a generative AI-powered digital spine of the EU energy system
  • Innovative tools and services to manage and empower energy communities
  • Underground Thermal Energy Storage in dense urban areas
  • New CO2 capture technologies
  • On-site innovative robotic and automated solutions and techniques for more sustainable and less disruptive building renovation and construction
  • Smarter buildings as part of the energy system for increased efficiency and flexibility – Societal Readiness Pilot
  • Innovative pathways for low carbon and climate resilient building stock and built environment (Built4People Partnership)
  • Innovative approaches for the deployment of Positive Energy Districts
  • Optimal combination of low embodied carbon construction products, technical building systems and circularity principles for climate neutral buildings (Built4People Partnership)
  • Phase out fossil fuel in energy intensive industries through the efficient integration of renewable energy sources

Cluster 6: Food, Bioeconomy, Natural Resources, Agriculture and Environment

Cluster 6: Food, Bioeconomy, Natural Resources, Agriculture and Environment

HORIZON-CL6-2025-01

17 september 2025

  • Additional activities for the European Biodiversity Partnership: Biodiversa+
  • Strengthening the capacity of citizen science in biodiversity observation
  • Strengthening taxonomic approaches for biodiversity
  • Large-scale in situ biodiversity observations for better understanding of biodiversity state, drivers of its decline and impacts of policies
  • Assessing and modelling ecosystems’ dynamic processes to guide restoration activities and to improve models used for climate
  • Assessing and modelling socio-economic impacts of nature restoration
  • Integrated and coordinated approaches for coral reefs and associated ecosystems (mangroves and seagrass beds) conservation, restoration, and climate mitigation and adaptation
  • Strengthening pathways to alternative socio-economic models for continuous improvement of biodiversity
  • Understanding the perceptions of and improving communication on the biodiversity crisis and nature restoration benefits to sustain citizen engagement and democratic governance
  • Supporting the implementation of nature restoration measures for sustainable farming systems
  • Novel circular business models to enable the just transition to a sustainable and circular economy
  • Improving ecodesign of products and development of testing methods for products prioritised under the Ecodesign for Sustainable Products Regulation
  • Product Environmental Footprint (PEF) of policy and market-relevant product groups
  • Development and testing of Extended Producer Responsibility schemes (EPR) within the priority Circular Economy Action Plan value chains
  • Consumption patterns and environmental awareness as enablers of transition to circular economy
  • Indicators for the transition to sustainable and circular economy
  • Demonstration, deployment and upscaling of circular systemic solutions in cities and regions (Circular Cities and Regions Initiative)
  • Bioprospecting and optimized production of the terrestrial natural products: new opportunities for bio-based sectors
  • Unleashing the potential and advancing the impact of the digitalization/Artificial Intelligence of the climate-neutral bio-based value chains
  • Support to the EU Biotechnology and Biomanufacturing Initiative: scoping action
  • Demonstration of reduced energy use and optimised flexible energy supply for industrial bio-based systems
  • Harmonizing and optimising composting plants performances in Europe
  • Reconstructing areas affected by conflicts: the role of the bio-based solutions
  • Bioprospecting and optimised production of marine/aquatic natural products in the omics & artificial intelligence era
  • European partnership: Forests and Forestry for a Sustainable Future
  • Innovative and advanced monitoring and modelling systems for revised air quality policies
  • Environmental impacts from the production of agricultural crops for bio-based industrial systems
  • Environmental biotechnology applications in service of remediation of polluted ecosystems
  • Towards a comprehensive European strategy to assess and monitor aquatic litter including plastic and microplastic pollution
  • EU-India cooperation on cumulative impacts of marine pollution on marine organisms and ecosystems
  • Provide digital solutions tailored to small and medium-sized farms to monitor and sustainably manage agricultural inputs and natural resources
  • Reducing pollution from the food and drink industries
Cluster 6: Food, Bioeconomy, Natural Resources, Agriculture and Environment

HORIZON-CL6-2025-01-two-stage

04 Septembre 2025

  • Living labs co-creating innovative solutions for forests and freshwater ecosystems restoration
  • Breeding for resilience: enhancing multi-stress tolerance in crops
  • Open Topic: Innovative solutions for the sustainable and circular transformation of SMEs
  • Substances of concern and emerging pollutants from bio-based industries and products: mapping and replacement
Cluster 6: Food, Bioeconomy, Natural Resources, Agriculture and Environment

HORIZON-CL6-2025-02-two-stage

04 Septembre 2025

  • Strengthening the resilience of water systems and water sector to climate and global socio-economic change impacts
  • Emerging and future risks to plant health
  • Open topic: Innovating for on-farm post-harvest operations, storage and transformation of crops into food and non-food products
  • Making food systems more resilient to food safety risks through the deployment of technological solutions
  • Research and innovation for food waste prevention and reduction at household level through measurement, monitoring and new technologies
  • Developing agroecology living labs and lighthouses for climate action under the Food and Nutrition Security and Sustainable Agriculture (FNSSA) partnership
Cluster 6: Food, Bioeconomy, Natural Resources, Agriculture and Environment

HORIZON-CL6-2025-02-two-stage

04 Septembre 2025

  • Strengthening the resilience of water systems and water sector to climate and global socio-economic change impacts
  • Emerging and future risks to plant health
  • Open topic: Innovating for on-farm post-harvest operations, storage and transformation of crops into food and non-food products
  • Making food systems more resilient to food safety risks through the deployment of technological solutions
  • Research and innovation for food waste prevention and reduction at household level through measurement, monitoring and new technologies
  • Developing agroecology living labs and lighthouses for climate action under the Food and Nutrition Security and Sustainable Agriculture (FNSSA) partnership
Cluster 6: Food, Bioeconomy, Natural Resources, Agriculture and Environment

HORIZON-CL6-2025-03

24 september 2025

  • Improving analytical capacity and understanding of the bargaining power and interactions of farmers with the operators of the value chains
  • Upscaling innovative payments to support farmers in the delivery of agri-environment-climate public goods
  • Boosting the attractiveness of agriculture and the connection between the farming community and society
  • Operationalisation of bioeconomy sustainability principles
  • Exploring options to resolve land and sea use competition
  • Strengthening and connecting bioeconomy networks
  • Strengthening the European Research Area by enhancing the bioeconomy research and innovation ecosystem in BIOEAST countries
  • Effective environmental observing systems and associated governance
  • Delivering Earth Intelligence to accelerate the green and digital transition
  • Improving and integrating polar observation systems in response to user requirements at local, regional, and international level
  • Enhancing sustainability and resilience of agriculture, forestry and rural development through digital twins
  • Increasing knowledge flows to practice within Agricultural Knowledge and Innovation Systems (AKIS) via thematic networks
  • Strengthening knowledge and skills of advisors and integrating them within Agricultural Knowledge and Innovation Systems (AKIS) via an EU advisory network
  • Preparing farmers, their workforce and advisors to the future of agriculture by providing the relevant knowledge, skills and competences at the right time and place

JU Circular Bio-based Europe Joint Undertaking

JU Circular Bio-based Europe Joint Undertaking

HORIZON-JU-CBE-2025

18 september 2025

  • Develop and deploy new curricula and knowledge exchange practices relevant to bio-based systems
  • Sustainable macroalgae systems for innovative, added-value applications: cultivation and optimised production systems
  • SSbD bio-based solutions to replace hazardous conventional chemicals for textiles production
  • Scaling-up nutritional proteins from alternative sources
  • Cost-effective and robust continuous biotech bio-based processes
  • SSbD bio-based polymers/copolymers unlocking new market applications
  • Urban-industrial symbiosis for bio-waste valorisation
  • HORIZON-JU-CBE-2025-IAFlag-02
  • Circular-by-design fibre-based packaging with improved properties
  • Retrofitting of (bio)refineries industrial plants towards higher-value bio-based products
  • Valorisation of untapped forest biomass
  • Bio-based and biodegradable delivery systems for fertilising products to reduce microplastics pollution & promote soil health
  • Alternative biomanufacturing routes for natural and synthetic rubber

MISSIONS

Adaptation to Climate Change

HORIZON-MISS-2025-01

24 september 2025

  • Supporting regions and local authorities in assessing climate risks
  • Supporting regional and local authorities in developing their Action Plans towards climate resilience
  • Demonstrating solutions to help hotspots in coastal regions to adapt to climate change
  • Testing and demonstrating innovative solutions to improve resilience to extreme heat, including addressing health impacts
  • Better understanding incentives for private sector financing of adaptation solutions
  • Support to the network of National Cancer Mission Hubs (NCMHs)
Cancer

HORIZON-MISS-2025-02

16 Septembre 2025

  • Sustained collaboration of national and regional cancer funders to support the Cancer Mission through translational research
  • Understanding the effects of environmental exposure on the risk of paediatric, adolescent and young adult cancers
  • Investigator-initiated multinational early-stage innovative clinical trials for paediatric cancer
  • Pragmatic clinical trials to enhance the quality of life of older cancer patients (65 years and older) through nutrition
  • Innovative surgery as the cornerstone of affordable multi-modal therapeutic interventions benefitting cancer patients with locally advanced or metastatic disease
  • Support to the network of National Cancer Mission Hubs (NCMHs)
Restore our Ocean and Waters by 2030

HORIZON-MISS-2025-03

24 september 2025

  • Blue Parks - Towards a coherent European network of strictly protected areas for restoring healthy and productive marine ecosystems
  • A toolbox for public authorities to address marine plastics and litter from river-to-ocean
  • Digital technologies and energy transition in fisheries and/or aquaculture
  • Restoring Ocean and Waters in Regions
  • Restoring Ocean and Waters in waterfront Cities and their Ports
  • Restoring Ocean and Waters on Islands
  • Mission Lighthouses coordination and support activities
  • EU Digital Twin Ocean: Contribution to the EU DTO core infrastructure through applications for sustainable ocean management
A Soil Deal for Europe

HORIZON-MISS-2025-05

30 september 2025

  • Living Labs for soil remediation and green redevelopment of brownfields
  • Social, economic and cultural drivers, and costs of land degradation
  • Increasing environmental resilience through a better knowledge and management of the soil-water nexus
  • Developing transfer functions for the Soil Monitoring Law
  • EU global footprint on soils
  • Quantifying the impact of farming practices on soil health in arable lands
  • Improved land suitability for soil health and sustainable biomass production
  • Support to the operation and further development of soil-health science-policy interfaces and national soil-health hubs
  • Citizen engagement for sustainable land management through local and regional authorities
  • Network on carbon farming and emissions reductions for agricultural and forest lands
  • Soil Salinity in Europe: Drivers, indicators, current levels and temporal changes

HORIZON-MISS-2025-05-two-stage

04 september 2025

  • Living labs to enhance soil health in Continental, Boreal and Alpine biogeographical regions
  • Broadening the living labs approach for soil health in Africa and Latin America and the Caribbean (LAC)

NEB Facility: A research agenda for a beautiful, inclusive and sustainable transformation of neighbourhoods

NEB Facility: A research agenda for a beautiful, inclusive and sustainable transformation of neighbourhoods

HORIZON-NEB-2025-01

12 November 2025

  • Renovating the built environment through design for adaptability and disassembly.
  • Bottom-up social entrepreneurship for the co-creation of neighbourhoods in line with the New European Bauhaus
  • Reverse local construction supply chains for the beautiful re-assembly of reclaimed construction products
  • The impact of common space on neighbourhood communities
  • Fostering and maintaining the social fabric for the green transition in neighbourhoods
  • Beautiful, sustainable and inclusive street furniture for the transformation of neighbourhoods
  • Network of neighbourhoods for innovative policies on gentrification
  • Applying regenerative design to the built environment in neighbourhoods
  • Bio-fabricated materials for sustainable and beautiful construction
  • Sufficiency measures in the built environment
  • Innovative approaches for sustainable, inclusive and beautiful social and affordable housing

WIDERA Hop-on facility

WIDERA Hop-on facility

HORIZON-WIDERA-2025-03

04 september 2025

  • Hop-on facility

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